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Universal Nutrition Since 1977
Made in a cGMP and HACCP certified facility on shared equipment processing milk, soy, egg, peanuts, tree nuts, fish, shellfish, wheat, and sesame. Contains 3mg melatonin per serving.
A 4-tier sleep formula in one nightly pack: Foundation (magnesium + zinc + vitamins) · Calm & Stress (ashwagandha + L-theanine) · Deep Sleep I (valerian + Zylaria) · Deep Sleep II (3mg melatonin). The full sleep architecture, not just melatonin alone.
3mg melatonin — moderate, not mega-dose
200mg L-theanine for the wind-down
300mg generic ashwagandha for cortisol
300mg magnesium (as oxide) for relaxation
Valerian + Zylaria proprietary botanical blend
Third-party tested every batch
What's Inside
De-Stress & Sleep is built in four layers — each targeting a different sleep mechanism. Foundational vitamins and minerals support the nervous system. Calm & Stress ingredients address cortisol and the wind-down. Deep Sleep I uses traditional botanical sedatives. Deep Sleep II uses 3mg melatonin for circadian timing. This is one of the more comprehensive sleep formulas in the daily-supplement category.
Foundation
Vit C/B6 + Magnesium + Zinc
- Vitamin C 200mg
- Vitamin B6 1.3mg
- Magnesium (as magnesium oxide) 300mg
- Zinc (as zinc oxide) 15mg
Foundational nervous-system cofactors. Honest note: magnesium here is the oxide form (less bioavailable than glycinate but inexpensive); 300mg is a substantial dose that compensates somewhat for the lower absorption rate. NIH ODS magnesium fact sheet covers the form comparison.
Calm & Stress
500mg combined adaptogens
- Ashwagandha extract 300mg (generic, not KSM-66)
- L-Theanine 200mg
Cortisol axis support (ashwagandha) plus the calming amino acid L-theanine. The ashwagandha here is generic extract at 300mg — useful, but not the KSM-66 standardized form used in the most-cited cortisol RCTs. For the KSM-66 form specifically (300–600mg/day clinical range), supplement separately from a dedicated KSM-66 brand.
Deep Sleep I
650mg botanical sedatives
- Valerian Root Powder 150mg
- Zylaria 500mg (Xylaria nigripes + Cuscuta + Panax notoginseng)
Traditional botanical sedatives that support sleep onset and depth via the GABAergic pathway. Valerian has documented sleep-onset effects in some adults; Zylaria is a more recent proprietary blend with growing evidence on sleep architecture.
Deep Sleep II — Melatonin
3mg per pack
- Melatonin 3mg
Moderate-dose melatonin for circadian timing support. Important: many adults respond better to lower doses (0.3–1mg) than higher — if 3mg leaves you groggy in the morning, you can take half a serving. This pack contains melatonin; if you prefer melatonin-free sleep support, this is NOT the right product (consider standalone magnesium glycinate, L-theanine, and ashwagandha capsules instead).
Full Supplement Facts
Per pack (one serving):
Foundation: Vitamin C 200mg · Vitamin B6 1.3mg · Magnesium 300mg (as magnesium oxide) · Zinc 15mg (as zinc oxide).
Calm & Stress: Ashwagandha Extract (Withania somnifera, leaf and/or root) 300mg · L-Theanine 200mg.
Deep Sleep I: Valerian Root Powder 150mg · Zylaria 500mg (Xylaria nigripes mycelium + Cuscuta chinensis extract seed + Panax notoginseng extract root).
Deep Sleep II: Melatonin 3mg.
Other ingredients: Hypromellose (cellulose capsules), microcrystalline cellulose, dicalcium phosphate, magnesium stearate, maltodextrin, turmeric root powder (for color).
Honest formulation notes:
- Magnesium form is OXIDE (cheap, ~4% bioavailability). 300mg dose partially compensates. Magnesium glycinate is the gold-standard form for sleep — if that specifically matters, supplement separately.
- Ashwagandha is generic extract, NOT KSM-66. For KSM-66 specifically, stack with Universal U's Ashwagandha Chews.
- Zinc form is oxide (also less bioavailable than picolinate or bisglycinate).
- Contains 3mg melatonin — disclose this if your prescriber asks about supplements.
How To Use
1
Take one pack 30–60 min before bed
With or without food. L-theanine works in ~30 min; melatonin peaks in 60–90 min. Time accordingly based on when you want to be asleep.
2
Pair with sleep hygiene
Dim lights 60–90 min before bed, cut caffeine by 2 PM, last meal 2–3 hours before sleep, consistent bedtime within a 30-min window. Supplements amplify good sleep hygiene; they don't replace it.
3
Find your right dose
Start with one full pack. If you wake up groggy, try a half-pack (split the capsules) the next night. Many adults respond better to lower melatonin doses; 3mg is on the higher end of evidence-backed dosing.
Who It's For
De-Stress & Sleep is for the adult who:
- Has trouble falling asleep because of cortisol-driven racing thoughts
- Wakes up frequently and wants deeper sleep architecture
- Wants a comprehensive sleep stack — not just melatonin alone
- Is OK taking melatonin (this pack contains 3mg)
- Doesn't already take separate magnesium / ashwagandha / valerian (would risk overstacking)
Not for you if: you prefer melatonin-free sleep support (this contains 3mg); you're pregnant or breastfeeding (ashwagandha + valerian + melatonin all flagged); you're on sedative medications, SSRIs, MAOIs, or other CNS-active prescriptions (interaction risk with valerian, ashwagandha, L-theanine, and melatonin compound); you're under 18; you operate machinery shortly after taking it.
How It Compares
De-Stress & Sleep sits in the multi-tier sleep formula category — distinct from melatonin-only or single-ingredient products. The honest comparison:
| Dimension | Universal U De-Stress & Sleep | Olly Sleep Gummies | Natural Vitality Calm + Sleep | Standalone magnesium glycinate + L-theanine + melatonin |
|---|---|---|---|---|
| Sleep mechanisms covered | 4 tiers (foundation, calm, deep, melatonin) ✓ | 2 (melatonin + L-theanine + some botanicals) | 2 (magnesium + melatonin) | Customizable |
| Magnesium dose | 300mg (as oxide) | None | 325mg (as glycinate ✓) | You choose form + dose |
| Magnesium form | Oxide (less bioavailable) | N/A | Glycinate ✓ | You choose |
| Ashwagandha | 300mg (generic extract) | None | None | You choose |
| L-Theanine | 200mg ✓ | 20–80mg (varies) | None | You choose |
| Melatonin dose | 3mg | 3mg | 0.5–1mg | You choose 0.3–3mg |
| Format | Capsule pack (5+ capsules/night) | Gummies (2g sugar) | Powder drink | Multiple bottles |
| Cost per night | ~$1.10 | ~$0.50 | ~$0.80 | ~$0.60–1.50 |
The bottom line: If you want comprehensive sleep architecture in one pack and don't already supplement magnesium/ashwagandha/valerian separately, De-Stress & Sleep is the most complete daily-use formula in the category. If you want premium magnesium glycinate (vs. oxide here), Natural Vitality Calm + Sleep is cleaner on that dimension. If you want zero added sugar gummies but with melatonin, Olly is the lighter option. If you want full dose customization, a standalone stack works but requires 3–4 bottles.
The Story Behind The Pack
Why a 4-tier sleep formula instead of just melatonin? What's the research behind valerian for sleep onset, L-theanine for the wind-down, and Zylaria for sleep architecture?
Sleep failure has multiple mechanisms — racing-thought cortisol, GABA dysregulation, magnesium deficiency, circadian timing misalignment. A formula that hits one mechanism (typically melatonin-only) leaves the others uncovered. De-Stress & Sleep stacks all four. Read more on women's daily wellness and sleep →
Frequently Asked Questions
Will De-Stress & Sleep make me groggy in the morning?
Possibly — the 3mg melatonin dose is on the higher end of evidence-backed dosing. Many adults respond better to 0.3–1mg melatonin. If you wake up groggy, take a half-pack (split the capsules) for several nights and assess. Valerian and Zylaria can also have mild morning sedation in sensitive individuals.
Why does De-Stress & Sleep use magnesium oxide instead of magnesium glycinate?
Honest answer: oxide is the most cost-effective magnesium form. The 300mg dose partially compensates for the lower (~4%) bioavailability vs. glycinate (~30%+). If magnesium glycinate matters to you specifically for sleep, supplement separately. NIH ODS covers magnesium forms.
Can I take De-Stress & Sleep every night?
For most adults, yes — the formula is designed for daily use. Some users cycle off melatonin (5 nights on, 2 off) to maintain natural circadian rhythm sensitivity. If you find you can't sleep without it after consistent use, that's a sign your natural cortisol/melatonin balance has shifted; talk to your provider.
Is the ashwagandha in De-Stress & Sleep KSM-66?
No — it's generic ashwagandha extract at 300mg per pack. KSM-66 is a specific patented full-spectrum standardized form used in most published clinical research on cortisol (including the 2012 Chandrasekhar RCT). If KSM-66 form matters to you for evidence reasons, supplement separately from a dedicated KSM-66 product (300–600mg/day clinical range from any reputable brand).
Can I take De-Stress & Sleep with antidepressants or anxiety medications?
Talk to your prescriber first. L-theanine, valerian, and ashwagandha all have theoretical interactions with SSRIs, SNRIs, MAOIs, benzodiazepines, and other CNS-active medications. Melatonin can also interact with blood thinners and immunosuppressants. The interaction risk is moderate — manageable with medical guidance, but not something to start without a conversation.
Is De-Stress & Sleep safe during pregnancy or breastfeeding?
No — not recommended. Ashwagandha, valerian, Zylaria, and melatonin are all flagged for caution during pregnancy and lactation. If you're trying to conceive, pregnant, or breastfeeding, do not take this product. Discuss safer sleep-support options with your OB-GYN.
What's the difference between De-Stress & Sleep and just taking melatonin alone?
Melatonin alone only addresses circadian timing — it tells your body it's time to be asleep. It doesn't help with cortisol-driven racing thoughts (that's where ashwagandha and L-theanine come in), wind-down (L-theanine), GABAergic relaxation (valerian, Zylaria), or the foundational nutrient cofactors (magnesium, zinc, B6, vitamin C). De-Stress & Sleep covers all four mechanisms; melatonin-only covers one.
Can I stack De-Stress & Sleep with my daily Total Health Pack?
Yes — designed to stack. Take the Women's or Men's Total Health Pack at breakfast (daily foundation). Take De-Stress & Sleep 60–90 minutes before bed on nights when stress, racing thoughts, or sleep latency are the issue. The Total Health Packs include 150mg of generic ashwagandha; De-Stress & Sleep adds 300mg more (plus L-theanine, valerian, Zylaria, magnesium 300mg, and 3mg melatonin) for the wind-down. Not designed for daily simultaneous use with another sleep supplement that contains melatonin.
Is De-Stress & Sleep vegan or vegetarian?
Vegetarian — yes (no animal-derived active ingredients; capsules are cellulose-based hypromellose). Vegan: the product is produced on shared equipment that processes milk, fish, and shellfish, so cross-contact is possible. For strict vegan compliance, confirm with manufacturer for current batch.
How does Subscribe & Save work for De-Stress & Sleep?
10% off every recurring order, delivered every 30 days by default (45 or 60-day cadences available). Skip any shipment any time. Cancel any time — no contract.
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